glp 1 sglt2 Mechanisms underlying favorable effects of GLP-1R agonists and SGLT2 Inhibitors vs. GLP-1 Agonists

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The decreased in GFR or albuminuria has been associated with the presence of nonalcoholic steatohepatitis or the severity of fibrosis, whereas improvement in liver histology is associated with improvement in CKD.75 arGLP1 improves insulin levels, regulates autophagy, inhibits hepatic neoglycogenesis, reduces hepatic fat content, plasma liver enzyme levels and hepatic histological improvements have been described with liraglutide and semaglutide.49,76 Likewise, epicardial and perirenal fat are associated with increased cardiorenal risk,77 so that the reduction in ectopic fat43 as demonstrated with the use of arGLP-1 has could be beneficial in CKD

The primary role of L-Carnitine is to shuttle fatty acids into the mitochondria for energy production

42:1027-1033 [PubMed: 30885951] 74